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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619570
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK3
Name: mitogen-activated protein kinase 3
Acc ID: CHEBI:472805
Term: ouabain
Definition: A steroid hormone that is a multi-hydroxylated alpha-L-rhamnosyl cardenoloide. It binds to and inhibits the plasma membrane Na(+)/K(+)-ATPase (sodium pump). It has been isolated naturally from Strophanthus gratus.
Chemical ID: MESH:D010042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK3decreases phosphorylationEXP 6480464CTDOuabain results in decreased phosphorylation of MAPK3 proteinPMID:28795476
MAPK3increases phosphorylationISOMapk3 (Rattus norvegicus)6480464CTDOuabain results in increased phosphorylation of MAPK3 proteinPMID:19687166
MAPK3multiple interactionsISOMapk3 (Rattus norvegicus)6480464CTDN-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased phosphorylation of MAPK3 protein]PMID:19687166
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