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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347433
Species: Homo sapiens
RGD Object: Gene
Symbol: TRPC6
Name: transient receptor potential cation channel subfamily C member 6
Acc ID: CHEBI:472805
Term: ouabain
Definition: A steroid hormone that is a multi-hydroxylated alpha-L-rhamnosyl cardenoloide. It binds to and inhibits the plasma membrane Na(+)/K(+)-ATPase (sodium pump). It has been isolated naturally from Strophanthus gratus.
Chemical ID: MESH:D010042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TRPC6increases expressionISOTrpc6 (Rattus norvegicus)6480464CTDOuabain results in increased expression of TRPC6 proteinPMID:19897708
TRPC6multiple interactionsISOTrpc6 (Rattus norvegicus)6480464CTDSLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]PMID:19897708
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