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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11243
Species: Mus musculus
RGD Object: Gene
Symbol: Rock2
Name: Rho-associated coiled-coil containing protein kinase 2
Acc ID: CHEBI:472805
Term: ouabain
Definition: A steroid hormone that is a multi-hydroxylated alpha-L-rhamnosyl cardenoloide. It binds to and inhibits the plasma membrane Na(+)/K(+)-ATPase (sodium pump). It has been isolated naturally from Strophanthus gratus.
Chemical ID: MESH:D010042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rock2increases cleavageISOROCK2 (Homo sapiens)6480464CTDOuabain results in increased cleavage of ROCK2 proteinPMID:20661774
Rock2multiple interactionsISOROCK2 (Homo sapiens)6480464CTDbenzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK2 protein]PMID:20661774
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