GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CAT | affects activity | EXP | | 6480464 | CTD | Arsenic affects the activity of CAT protein | PMID:23353816 | CAT | increases response to substance | EXP | | 6480464 | CTD | CAT gene polymorphism results in increased susceptibility to Arsenic | PMID:14580687 | CAT | multiple interactions | EXP | | 6480464 | CTD | [Palmitic Acid co-treated with Arsenic] affects the expression of CAT mRNA; Arsenic promotes the reaction [Selenium results in increased expression of CAT protein]; CAT protein inhibits the reaction [[[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased expression of HIF1A protein] which results in increased expression of VEGFA mRNA]; CAT protein inhibits the reaction [[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased expression of HIF1A protein]; CAT protein inhibits the reaction [[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CAT protein inhibits the reaction [[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; CAT protein inhibits the reaction [Arsenic promotes the reaction [Humic Substances results in decreased activity of PLG protein]]; CAT protein inhibits the reaction [Arsenic results in increased expression of and results in increased activity of CTNNB1 protein] | PMID:11419606 PMID:20478284 PMID:21687637 PMID:22552367 PMID:33736254 | CAT | affects activity | ISO | Cat (Rattus norvegicus) | 6480464 | CTD | Arsenic affects the activity of CAT protein | PMID:22434702 | CAT | decreases activity | ISO | Cat (Rattus norvegicus) | 6480464 | CTD | Arsenic results in decreased activity of CAT protein | PMID:21219961 PMID:21864513 PMID:22120977 PMID:22229868 PMID:22704994 PMID:24295472 PMID:30324125 PMID:36813806 PMID:36850985 | CAT | decreases activity | ISO | Cat (Mus musculus) | 6480464 | CTD | Arsenic results in decreased activity of CAT protein | PMID:10930056 PMID:27289040 PMID:29741077 | CAT | decreases expression | ISO | Cat (Mus musculus) | 6480464 | CTD | Arsenic results in decreased expression of CAT protein | PMID:22552367 | CAT | multiple interactions | ISO | Cat (Rattus norvegicus) | 6480464 | CTD | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [Sodium Fluoride results in increased abundance of Fluorides]] results in decreased activity of CAT protein; [Arsenic co-treated with Cadmium co-treated with Lead co-treated with Mercury co-treated with Chromium co-treated with Nickel co-treated with Manganese co-treated with Iron] results in decreased activity of CAT protein; [Arsenic co-treated with quinalphos] results in decreased activity of CAT protein; [Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of CAT protein]; [sodium arsenite results in increased abundance of Arsenic] which affects the activity of CAT protein; [sodium arsenite results in increased abundance of Arsenic] which affects the expression of CAT mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in decreased activity of CAT protein; [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CAT mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CAT mRNA; Acetaminophen promotes the reaction [Arsenic results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased activity of CAT protein]; Ascorbic Acid inhibits the reaction [Arsenic results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Arsenic results in decreased activity of CAT protein]; diallyl trisulfide inhibits the reaction [Arsenic results in decreased activity of CAT protein]; ferulic acid inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased activity of CAT protein]; fisetin inhibits the reaction [Arsenic results in decreased activity of CAT protein]; nobiletin inhibits the reaction [Arsenic results in decreased activity of CAT protein]; Plant Extracts inhibits the reaction [Arsenic results in decreased activity of CAT protein]; Silybin inhibits the reaction [Arsenic results in decreased activity of CAT protein]; Succimer inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased activity of CAT protein]; sulforaphane inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased activity of CAT protein]; sulforaphane inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CAT mRNA]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased activity of CAT protein] | PMID:17176674 PMID:21219961 PMID:22120977 PMID:22229868 PMID:22704994 PMID:24295472 PMID:30324125 PMID:30835071 PMID:31584213 PMID:32270456 PMID:32402895 PMID:33127376 PMID:33171135 PMID:33609566 PMID:36757007 PMID:36813806 PMID:36822304 PMID:36850985 | CAT | multiple interactions | ISO | Cat (Mus musculus) | 6480464 | CTD | [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of CAT protein; [[sodium arsenite results in increased abundance of Arsenic] which co-treated with epigallocatechin gallate] results in decreased activity of CAT protein; [methylmercuric chloride co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of CAT protein; [sodium arsenite results in increased abundance of Arsenic] promotes the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in decreased activity of CAT protein]; [sodium arsenite results in increased abundance of Arsenic] which results in decreased activity of CAT protein; [sodium arsenite results in increased abundance of Arsenic] which results in increased activity of CAT protein; [Sodium Fluoride results in increased abundance of Fluorides] promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased activity of CAT protein]; biochanin A inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased activity of CAT protein]; Dietary Fats promotes the reaction [Arsenic results in decreased activity of CAT protein]; epigallocatechin gallate inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased activity of CAT protein] | PMID:29741077 PMID:31350662 PMID:32179164 PMID:33148380 PMID:33410021 PMID:35714946 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |