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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730821
Species: Homo sapiens
RGD Object: Gene
Symbol: MMP2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:47217
Term: arsane
Definition: An arsine that has formula 77.94542.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MMP2increases expressionEXP 6480464CTDArsenic results in increased expression of MMP2 proteinPMID:26721309
MMP2multiple interactionsEXP 6480464CTD[Arsenic co-treated with RET protein alternative form] results in increased secretion of MMP2 protein alternative form; [Arsenic co-treated with RET protein] results in increased secretion of MMP2 protein alternative form; [Arsenic results in increased expression of and results in increased secretion of MMP2 protein] which results in increased expression of VCAM1 protein; [Silybin co-treated with Arsenic] results in decreased expression of MMP2; Arsenic results in increased expression of and results in increased secretion of MMP2 protein; Cysteine inhibits the reaction [[Arsenic co-treated with RET protein] results in increased secretion of MMP2 protein alternative form]; MIR143 mRNA inhibits the reaction [Arsenic results in increased expression of MMP2 protein]PMID:21195159 PMID:25868784 PMID:26637202 PMID:26721309
MMP2increases expressionISOMmp2 (Rattus norvegicus)6480464CTDArsenic results in increased expression of MMP2 mRNAPMID:18315880
MMP2multiple interactionsISOMmp2 (Rattus norvegicus)6480464CTD[sodium arsenite results in increased abundance of Arsenic] which results in increased activity of MMP2 protein; mecobalamin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased activity of MMP2 protein]PMID:33739591
MMP2multiple interactionsISOMmp2 (Mus musculus)6480464CTD[sodium arsenite results in increased abundance of Arsenic] which results in increased secretion of MMP2 proteinPMID:37527016
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