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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70952
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsto1
Name: glutathione S-transferase omega 1
Acc ID: CHEBI:47217
Term: arsane
Definition: An arsine that has formula 77.94542.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsto1affects abundanceISOGSTO1 (Homo sapiens)6480464CTDGSTO1 gene polymorphism affects the abundance of Arsenic metabolitePMID:24239724
Gsto1affects metabolic processingISOGSTO1 (Homo sapiens)6480464CTDGSTO1 gene SNP affects the metabolism of ArsenicPMID:21094982 PMID:27327299
Gsto1affects response to substanceISOGSTO1 (Homo sapiens)6480464CTDGSTO1 gene polymorphism affects the susceptibility to ArsenicPMID:28436716
Gsto1decreases metabolic processingISOGSTO1 (Homo sapiens)6480464CTDGSTO1 protein polymorphism results in decreased metabolism of ArsenicPMID:15901998
Gsto1increases metabolic processingISOGSTO1 (Homo sapiens)6480464CTDGSTO1 protein results in increased metabolism of ArsenicPMID:16638819 PMID:18414634
Gsto1increases response to substanceISOGSTO1 (Homo sapiens)6480464CTDGSTO1 gene SNP results in increased susceptibility to ArsenicPMID:29323258
Gsto1multiple interactionsISOGSTO1 (Homo sapiens)6480464CTD[Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GSTO1 mRNA; [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of GSTO1 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of GSTO1 mRNA; Arsenic affects the reaction [GSTO1 gene alternative form results in increased expression of APAF1 mRNA]; Arsenic affects the reaction [GSTO1 gene alternative form results in increased expression of CXCL8 mRNA]; GSTO1 gene polymorphism affects the metabolism of and affects the susceptibility to Arsenic; GSTO1 gene polymorphism affects the reaction [PNP gene polymorphism affects the susceptibility to Arsenic]; GSTO1 gene SNP affects the metabolism of and affects the abundance of ArsenicPMID:14680363 PMID:17548696 PMID:21605854 PMID:22293942 PMID:32452228 PMID:33434570
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