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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70952
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsto1
Name: glutathione S-transferase omega 1
Acc ID: CHEBI:47217
Term: arsane
Definition: An arsine that has formula 77.94542.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects abundanceISORGD:13453316480464CTDGSTO1 gene polymorphism affects the abundance of Arsenic metabolite

PMID:24239724
affects metabolic processingISORGD:13453316480464CTDGSTO1 gene SNP affects the metabolism of Arsenic

PMID:21094982, PMID:27327299
decreases metabolic processingISORGD:13453316480464CTDGSTO1 protein polymorphism results in decreased metabolism of Arsenic

PMID:15901998
increases metabolic processingISORGD:13453316480464CTDGSTO1 protein results in increased metabolism of Arsenic

PMID:16638819, PMID:18414634
multiple interactionsISORGD:13453316480464CTDArsenic affects the reaction [GSTO1 gene alternative form results in increased expression of APAF1 mRNA], Arsenic affects the reaction [GSTO1 gene alternative form results in increased expression of CXCL8 mRNA], GSTO1 gene polymorphism affects the metabolism of and affects the susceptibility to Arsenic, GSTO1 gene polymorphism affects the reaction [PNP gene polymorphism affects the susceptibility to Arsenic]

PMID:14680363, PMID:17548696, PMID:21605854, PMID:22293942
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.