GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CCND1 | affects response to substance | EXP | | 6480464 | CTD | CCND1 promoter affects the susceptibility to Arsenic | PMID:29103775 | CCND1 | increases expression | EXP | | 6480464 | CTD | Arsenic results in increased expression of CCND1 mRNA; Arsenic results in increased expression of CCND1 protein | PMID:17306315 PMID:19945496 PMID:21514422 | CCND1 | multiple interactions | EXP | | 6480464 | CTD | [Genistein co-treated with Lapatinib] affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of CCND1 protein]; [Silybin co-treated with Arsenic] results in decreased expression of CCND1 protein; [sodium arsenite results in increased abundance of Arsenic] which affects the expression of CCND1 protein; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CCND1 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CCND1 protein; Arsenic inhibits the reaction [Estradiol results in increased expression of CCND1 protein]; Calcitriol inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CCND1 mRNA]; Calcitriol inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CCND1 protein]; CXCL8 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of CCND1 protein]; ERBB2 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of CCND1 protein]; Genistein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of CCND1 protein]; Genistein affects the reaction [ERBB2 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of CCND1 protein]]; Lapatinib affects the reaction [CXCL8 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of CCND1 protein]]; LY 290042 affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of CCND1 protein]; LY 290042 affects the reaction [CXCL8 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of CCND1 protein]]; reparixin affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of CCND1 protein]; stattic affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of CCND1 protein]; U 0126 affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of CCND1 protein]; U 0126 affects the reaction [CXCL8 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of CCND1 protein]] | PMID:25868784 PMID:33047385 PMID:33396024 PMID:36504884 | CCND1 | increases expression | ISO | Ccnd1 (Mus musculus) | 6480464 | CTD | Arsenic results in increased expression of CCND1 mRNA | PMID:15026472 | | ||||||||||||||||||||||
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