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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:47217
Term: arsane
Definition: An arsine that has formula 77.94542.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects response to substanceISORGD:685566480464CTDCCND1 promoter affects the susceptibility to Arsenic

PMID:29103775
increases expressionISORGD:685566480464CTDArsenic results in increased expression of CCND1 mRNA, Arsenic results in increased expression of CCND1 protein

PMID:17306315, PMID:19945496, PMID:21514422
increases expressionISORGD:685576480464CTDArsenic results in increased expression of CCND1 mRNA

PMID:15026472
multiple interactionsISORGD:685566480464CTD[silybin co-treated with Arsenic] results in decreased expression of CCND1 protein

PMID:25868784
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.