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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:47217
Term: arsane
Definition: An arsine that has formula 77.94542.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxdecreases expressionEXP 6480464CTDArsenic results in decreased expression of BAX proteinPMID:11756236
Baxmultiple interactionsEXP 6480464CTD[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BAX mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BAX protein; Acetylcysteine inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BAX mRNA]; Succimer inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BAX mRNA]; sulforaphane inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BAX mRNA]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BAX mRNA]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BAX protein]PMID:30835071 PMID:32402895 PMID:36822304
Baxincreases expressionISOBax (Mus musculus)6480464CTDArsenic results in increased expression of BAX proteinPMID:27289040
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDArsenic results in increased expression of BAX mRNAPMID:29864498 PMID:30081983
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[sodium arsenite results in increased abundance of Arsenic] promotes the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased expression of BAX mRNA]; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BAX mRNA; [Sodium Fluoride results in increased abundance of Fluorides] promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BAX mRNA]PMID:35714946
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in decreased expression of BAX protein; [Palmitic Acid co-treated with Arsenic] affects the expression of BAX mRNAPMID:32802178 PMID:33736254
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