GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | PARP1 | decreases expression | EXP | | 6480464 | CTD | Arsenic results in decreased expression of PARP1 mRNA; Arsenic results in decreased expression of PARP1 protein | PMID:21332098 PMID:35490796 | PARP1 | multiple interactions | EXP | | 6480464 | CTD | [[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein; [EHMT2 protein co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of PARP1 mRNA; [EHMT2 protein co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of PARP1 protein; [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of PARP1 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of PARP1 protein; [sodium arsenite results in increased abundance of Arsenic] which results in increased cleavage of PARP1 protein; AKT1 protein modified form inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]]; BIX 01294 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of PARP1 protein]; Curcumin inhibits the reaction [Arsenic results in decreased expression of PARP1 mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of PARP1 protein]; Ginkgo biloba extract inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of PARP1 mRNA]; MCL1 protein affects the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]; MCL1 protein inhibits the reaction [Sirolimus inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]]; MCL1 protein inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]]; MCL1 protein promotes the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]; NFE2L1 protein alternative form inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased cleavage of PARP1 protein]; S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased expression of PARP1 mRNA]; Sirolimus inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]; USP7 protein affects the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]; Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein] | PMID:21332098 PMID:32188015 PMID:32802178 PMID:33378118 PMID:35490796 | PARP1 | increases cleavage | ISO | Parp1 (Rattus norvegicus) | 6480464 | CTD | Arsenic results in increased cleavage of PARP1 protein | PMID:28903487 | PARP1 | multiple interactions | ISO | Parp1 (Rattus norvegicus) | 6480464 | CTD | [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Zinc deficiency] results in increased cleavage of PARP1 protein; BDNF protein inhibits the reaction [Arsenic results in increased cleavage of PARP1 protein]; NOG protein inhibits the reaction [Arsenic results in increased cleavage of PARP1 protein]; staurosporine aglycone inhibits the reaction [NOG protein inhibits the reaction [Arsenic results in increased cleavage of PARP1 protein]] | PMID:28903487 PMID:31542844 | | ||||||||||||||||||||||
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