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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310764
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsto2
Name: glutathione S-transferase omega 2
Acc ID: CHEBI:47217
Term: arsane
Definition: An arsine that has formula 77.94542.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsto2affects metabolic processingISOGSTO2 (Homo sapiens)6480464CTDGSTO2 gene SNP affects the metabolism of ArsenicPMID:21094982
Gsto2affects response to substanceISOGSTO2 (Homo sapiens)6480464CTDGSTO2 gene polymorphism affects the susceptibility to Arsenic; GSTO2 gene SNP affects the susceptibility to ArsenicPMID:20045512 PMID:21094982
Gsto2increases metabolic processingISOGSTO2 (Homo sapiens)6480464CTDGSTO2 protein results in increased metabolism of ArsenicPMID:16638819 PMID:18414634
Gsto2increases response to substanceISOGSTO2 (Homo sapiens)6480464CTDGSTO2 gene SNP results in increased susceptibility to ArsenicPMID:29323258
Gsto2multiple interactionsISOGSTO2 (Homo sapiens)6480464CTD[Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GSTO2 mRNA; [GSTO2 gene polymorphism affects the metabolism of Arsenic] which affects the abundance of Cacodylic Acid; [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of GSTO2 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of GSTO2 mRNA; GSTO2 gene polymorphism affects the reaction [PNP gene polymorphism affects the susceptibility to Arsenic]PMID:21605854 PMID:32650499 PMID:33434570
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