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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10512
Species: Mus musculus
RGD Object: Gene
Symbol: Egr1
Name: early growth response 1
Acc ID: CHEBI:47217
Term: arsane
Definition: An arsine that has formula 77.94542.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egr1affects expressionISOEGR1 (Homo sapiens)6480464CTDArsenic affects the expression of EGR1 mRNAPMID:28793237
Egr1decreases methylationISOEGR1 (Homo sapiens)6480464CTDArsenic results in decreased methylation of EGR1 promoterPMID:35490796
Egr1increases expressionISOEGR1 (Homo sapiens)6480464CTDArsenic results in increased expression of EGR1 mRNAPMID:18039032
Egr1multiple interactionsISOEGR1 (Homo sapiens)6480464CTD[Arsenic results in increased abundance of Cacodylic Acid] which affects the expression of EGR1 mRNA; [Folic Acid co-treated with Arsenic] affects the expression of EGR1 mRNA; [S-Adenosylmethionine co-treated with Arsenic] affects the expression of EGR1 mRNA; [S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of EGR1 promoter]] which results in decreased expression of EGR1 mRNA; Folic Acid inhibits the reaction [Arsenic results in decreased methylation of EGR1 promoter]; S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of EGR1 promoter]PMID:28793237 PMID:35490796
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