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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734431
Species: Homo sapiens
RGD Object: Gene
Symbol: NFE2L2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:47105
Term: 1-bromopropane
Definition: A bromoalkane that is propane carrying a bromo substituent at position 1.
Chemical ID: MESH:C118559
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NFE2L2decreases expressionISONfe2l2 (Rattus norvegicus)6480464CTD1-bromopropane results in decreased expression of NFE2L2 mRNAPMID:27452781
NFE2L2decreases response to substanceISONfe2l2 (Mus musculus)6480464CTDNFE2L2 results in decreased susceptibility to 1-bromopropanePMID:20211940
NFE2L2multiple interactionsISONfe2l2 (Mus musculus)6480464CTDNFE2L2 promotes the reaction [1-bromopropane results in increased expression of GCLC mRNA]; NFE2L2 promotes the reaction [1-bromopropane results in increased expression of GCLM mRNA]; NFE2L2 promotes the reaction [1-bromopropane results in increased expression of GSR mRNA]; NFE2L2 promotes the reaction [1-bromopropane results in increased expression of HMOX1 mRNA]; NFE2L2 promotes the reaction [1-bromopropane results in increased expression of NQO1 mRNA]PMID:20211940
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