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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731006
Species: Homo sapiens
RGD Object: Gene
Symbol: PTGS2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:47105
Term: 1-bromopropane
Definition: A bromoalkane that is propane carrying a bromo substituent at position 1.
Chemical ID: MESH:C118559
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PTGS2increases expressionEXP 6480464CTD1-bromopropane results in increased expression of PTGS2 mRNAPMID:22353212
PTGS2increases expressionISOPtgs2 (Mus musculus)6480464CTD1-bromopropane results in increased expression of PTGS2 mRNAPMID:22353212
PTGS2multiple interactionsISOPtgs2 (Mus musculus)6480464CTD1-bromopropane results in increased expression of and results in increased activity of PTGS2 protein; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [1-bromopropane results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1-bromopropane results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [1-bromopropane results in increased expression of PTGS2 protein]PMID:22353212
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