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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731747
Species: Mus musculus
RGD Object: Gene
Symbol: Ptpn11
Name: protein tyrosine phosphatase, non-receptor type 11
Acc ID: CHEBI:4708
Term: doxazosin
Definition: A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure.
Chemical ID: MESH:D017292
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptpn11multiple interactionsEXP 6480464CTD[Doxazosin results in increased phosphorylation of and results in increased activity of EPHA2 protein] which results in increased phosphorylation of and results in increased activity of PTPN11 proteinPMID:22845314
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