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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2654
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gadd45a
Name: growth arrest and DNA-damage-inducible, alpha
Acc ID: CHEBI:46936
Term: nonivamide
Definition: A capsaicinoid that is the carboxamide resulting from the formal condensation of the amino group of 4-hydroxy-3-methoxybenzylamine with the carboxy group of nonanoic acid. It is the active ingredient in many pepper sprays.
Chemical ID: MESH:C040937
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gadd45aincreases expressionISORGD:7338036480464CTDnonivamide results in increased expression of GADD45A mRNA

PMID:17332266
Gadd45amultiple interactionsISORGD:7338036480464CTD[nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of GADD45A mRNA

PMID:17332266
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