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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1589591
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eif2a
Name: eukaryotic translation initiation factor 2A
Acc ID: CHEBI:46936
Term: nonivamide
Definition: A capsaicinoid that is the carboxamide resulting from the formal condensation of the amino group of 4-hydroxy-3-methoxybenzylamine with the carboxy group of nonanoic acid. It is the active ingredient in many pepper sprays.
Chemical ID: MESH:C040937
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif2adecreases response to substanceISORGD:16050266480464CTDEIF2A protein results in decreased susceptibility to nonivamide

PMID:17332266
Eif2aincreases phosphorylationISORGD:16050266480464CTDnonivamide results in increased phosphorylation of EIF2A protein

PMID:17332266
Eif2amultiple interactionsISORGD:16050266480464CTD[nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of EIF2A protein [nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased phosphorylation of EIF2A protein salubrinal inhibits the reaction [EIF2A protein results in decreased susceptibility to nonivamide]

PMID:17332266
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