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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11429
Species: Mus musculus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:469
Term: 1'-acetoxychavicol acetate
Definition: An acetate ester that is chavicol acetate substituted by an acetoxy group at position 1'.
Chemical ID: MESH:C047948
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTD1'-acetoxychavicol acetate inhibits the reaction [TNF protein affects the localization of RELA protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased activity of CHUK protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased activity of IKBKB protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased activity of RELA protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BIRC3 protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of BIRC5 protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of CFLAR protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of IKBKB protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of MAP3K14 protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of MYC protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of TNFRSF1A protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of TRADD protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of TRAF1 protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of TRAF2 protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of XIAP protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; 1'-acetoxychavicol acetate promotes the reaction [TNF protein results in increased cleavage of PARP1 protein]PMID:15905586
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