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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62126
Species: Mus musculus
RGD Object: Gene
Symbol: Fkbp1b
Name: FK506 binding protein 1b
Acc ID: CHEBI:4681
Term: dofetilide
Definition: A tertiary amino compound that is N-ethyl-N-methylethanamine substituted by a 4-[(methylsulfonyl)amino]phenoxy and a 4-[(methylsulfonyl)amino]phenyl group at the terminal carbon atoms respectively. It is used as an anti-arrhythmia drug.
Chemical ID: MESH:C063533
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fkbp1bmultiple interactionsISOFkbp1b (Rattus norvegicus)6480464CTDdofetilide inhibits the reaction [Isoproterenol results in decreased expression of FKBP1B mRNA]; dofetilide inhibits the reaction [Isoproterenol results in decreased expression of FKBP1B protein]PMID:20723002
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