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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733046
Species: Mus musculus
RGD Object: Gene
Symbol: Prop1
Name: paired like homeodomain factor 1
Acc ID: CHEBI:4670
Term: dobutamine
Definition: A catecholamine that is 4-(3-aminobutyl)phenol in which one of the hydrogens attached to the nitrogen is substituted by a 2-(3,4-dihydroxyphenyl)ethyl group. A beta1-adrenergic receptor agonist that has cardiac stimulant action without evoking vasoconstriction or tachycardia, it is used as the hydrochloride to increase the contractility of the heart in the management of acute heart failure.
Chemical ID: MESH:D004280
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prop1decreases response to substanceEXP 6480464CTDPROP1 gene mutant form results in decreased susceptibility to DobutaminePMID:19414510
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