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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69099
Species: Mus musculus
RGD Object: Gene
Symbol: Kcnj11
Name: potassium inwardly rectifying channel, subfamily J, member 11
Acc ID: CHEBI:4670
Term: dobutamine
Definition: A catecholamine that is 4-(3-aminobutyl)phenol in which one of the hydrogens attached to the nitrogen is substituted by a 2-(3,4-dihydroxyphenyl)ethyl group. A beta1-adrenergic receptor agonist that has cardiac stimulant action without evoking vasoconstriction or tachycardia, it is used as the hydrochloride to increase the contractility of the heart in the management of acute heart failure.
Chemical ID: MESH:D004280
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnj11affects response to substanceEXP 6480464CTDKCNJ11 protein affects the susceptibility to DobutaminePMID:17189350
Kcnj11multiple interactionsEXP 6480464CTDKCNJ11 protein affects the reaction [[Manganese co-treated with Dobutamine] results in increased abundance of Calcium]PMID:17189350
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