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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62279
Species: Mus musculus
RGD Object: Gene
Symbol: Phgdh
Name: 3-phosphoglycerate dehydrogenase
Acc ID: CHEBI:4670
Term: dobutamine
Definition: A catecholamine that is 4-(3-aminobutyl)phenol in which one of the hydrogens attached to the nitrogen is substituted by a 2-(3,4-dihydroxyphenyl)ethyl group. A beta1-adrenergic receptor agonist that has cardiac stimulant action without evoking vasoconstriction or tachycardia, it is used as the hydrochloride to increase the contractility of the heart in the management of acute heart failure.
Chemical ID: MESH:D004280
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:619876480464CTDDobutamine results in increased expression of PHGDH mRNA

PMID:12423672
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.