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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69096
Species: Mus musculus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:46680
Term: serpentine asbestos
Definition: null
Chemical ID: MESH:D017632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1affects expressionEXP 6480464CTDAsbestos, Serpentine affects the expression of TGFB1 proteinPMID:26699812
Tgfb1increases activityEXP 6480464CTDAsbestos, Serpentine results in increased activity of TGFB1 proteinPMID:18569384
Tgfb1increases expressionEXP 6480464CTDAsbestos, Serpentine results in increased expression of TGFB1; Asbestos, Serpentine results in increased expression of TGFB1 mRNA; Asbestos, Serpentine results in increased expression of TGFB1 proteinPMID:18039278 PMID:19105532 PMID:19817698 PMID:25324550
Tgfb1multiple interactionsEXP 6480464CTDAsbestos, Serpentine promotes the reaction [TNF protein results in increased expression of TGFB1 mRNA]; STAT6 protein affects the reaction [Asbestos, Serpentine affects the expression of TGFB1 protein]; TGFB1 protein affects the reaction [Asbestos, Serpentine results in increased expression of CCN2]PMID:18569384 PMID:19817698 PMID:26699812
Tgfb1increases expressionISOTgfb1 (Rattus norvegicus)6480464CTDAsbestos, Serpentine results in increased expression of TGFB1 proteinPMID:18569384
Tgfb1increases expressionISOTGFB1 (Homo sapiens)6480464CTDAsbestos, Serpentine results in increased expression of TGFB1 proteinPMID:26685284
Tgfb1increases secretionISOTGFB1 (Homo sapiens)6480464CTDAsbestos, Serpentine results in increased secretion of TGFB1 proteinPMID:25358858 PMID:30609805
Tgfb1multiple interactionsISOTGFB1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Serpentine results in increased secretion of TGFB1 protein]; pyrazolanthrone inhibits the reaction [Asbestos, Serpentine results in increased secretion of TGFB1 protein]; SB 203580 inhibits the reaction [Asbestos, Serpentine results in increased secretion of TGFB1 protein]; TGFB1 protein affects the reaction [Asbestos, Serpentine results in decreased expression of CDH1 protein]; TGFB1 protein affects the reaction [Asbestos, Serpentine results in decreased expression of CTNNB1 protein]; TGFB1 protein affects the reaction [Asbestos, Serpentine results in increased expression of ACTA2 protein]; TGFB1 protein affects the reaction [Asbestos, Serpentine results in increased expression of FN1 protein]; TGFB1 protein affects the reaction [Asbestos, Serpentine results in increased expression of VIM protein]PMID:25358858 PMID:26685284 PMID:30609805
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