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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732766
Species: Mus musculus
RGD Object: Gene
Symbol: Ogg1
Name: 8-oxoguanine DNA-glycosylase 1
Acc ID: CHEBI:46666
Term: crocidolite asbestos
Definition: null
Chemical ID: MESH:D017638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ogg1increases response to substanceEXP 6480464CTDOGG1 protein mutant form results in increased susceptibility to Asbestos, CrocidolitePMID:24918270
Ogg1multiple interactionsEXP 6480464CTDOGG1 protein mutant form promotes the reaction [Asbestos, Crocidolite results in increased expression of CASP3 protein modified form]; OGG1 protein mutant form promotes the reaction [Asbestos, Crocidolite results in increased expression of HSPA5 protein]; OGG1 protein mutant form promotes the reaction [Asbestos, Crocidolite results in increased expression of TRP53 protein]PMID:24918270
Ogg1increases expressionISOOGG1 (Homo sapiens)6480464CTDAsbestos, Crocidolite results in increased expression of OGG1 mRNAPMID:11181447
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