GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | MAP2K1 | affects expression | EXP | | 6480464 | CTD | Asbestos, Crocidolite affects the expression of MAP2K1 mRNA | PMID:24160326 | MAP2K1 | increases phosphorylation | EXP | | 6480464 | CTD | Asbestos, Crocidolite results in increased phosphorylation of MAP2K1 protein | PMID:18314537 | MAP2K1 | multiple interactions | ISO | Map2k1 (Mus musculus) | 6480464 | CTD | MAP2K1 protein affects the reaction [Asbestos, Crocidolite results in increased expression of SCGB1A1 mRNA]; MAP2K1 protein affects the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK1 protein]; MAP2K1 protein affects the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK3 protein]; MAP2K1 protein inhibits the reaction [Asbestos, Crocidolite results in increased expression of COL1A1 mRNA]; MAP2K1 protein inhibits the reaction [Asbestos, Crocidolite results in increased expression of COL3A1 mRNA]; MAP2K1 protein inhibits the reaction [Asbestos, Crocidolite results in increased expression of IL6 mRNA] | PMID:18192500 | | ||||||||||||||||||||||
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