Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352582
Species: Homo sapiens
RGD Object: Gene
Symbol: IL6
Name: interleukin 6
Acc ID: CHEBI:46666
Term: crocidolite asbestos
Definition: null
Chemical ID: MESH:D017638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL6affects expressionEXP 6480464CTDAsbestos, Crocidolite affects the expression of IL6 proteinPMID:25757056
IL6increases expressionEXP 6480464CTDAsbestos, Crocidolite results in increased expression of IL6 mRNA; Asbestos, Crocidolite results in increased expression of IL6 proteinPMID:11250057 PMID:18687144 PMID:23937860 PMID:25757056 PMID:28056339 PMID:9378980
IL6increases secretionEXP 6480464CTDAsbestos, Crocidolite results in increased secretion of IL6 proteinPMID:10022265 PMID:19041333 PMID:21762757 PMID:23937860 PMID:28056339 PMID:9378980
IL6multiple interactionsEXP 6480464CTD1,2-Dipalmitoylphosphatidylcholine inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL6 protein]; 1,3-dimethylthiourea inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL6 protein]; Asbestos, Crocidolite promotes the reaction [CEBPB protein binds to IL6 promoter]; Asbestos, Crocidolite promotes the reaction [NFKB1 protein binds to IL6 promoter]; Asbestos, Crocidolite promotes the reaction [RELA protein binds to IL6 promoter]; Asbestos, Crocidolite promotes the reaction [TNF protein results in increased secretion of IL6 protein]; Dimethyl Sulfoxide inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL6 protein]; IL1RN protein inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL6 protein]; Interleukin 1 Receptor Antagonist Protein inhibits the reaction [Asbestos, Crocidolite results in increased expression of IL6 mRNA]; Interleukin 1 Receptor Antagonist Protein inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL6 protein]; NLRP3 protein affects the reaction [Asbestos, Crocidolite results in increased secretion of IL6 protein]; prolinedithiocarbamate inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL6 protein]; tetramethylthiourea inhibits the reaction [Asbestos, Crocidolite promotes the reaction [CEBPB protein binds to IL6 promoter]]; tetramethylthiourea inhibits the reaction [Asbestos, Crocidolite promotes the reaction [NFKB1 protein binds to IL6 promoter]]; tetramethylthiourea inhibits the reaction [Asbestos, Crocidolite promotes the reaction [RELA protein binds to IL6 promoter]]; tetramethylthiourea inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL6 protein]; TNF protein inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL6 protein]; TNF protein promotes the reaction [Asbestos, Crocidolite results in increased secretion of IL6 protein]PMID:10022265 PMID:19041333 PMID:21762757 PMID:23937860 PMID:28056339 PMID:9378980
IL6affects expressionISOIl6 (Mus musculus)6480464CTDAsbestos, Crocidolite affects the expression of IL6 mRNAPMID:22293422
IL6increases expressionISOIl6 (Mus musculus)6480464CTDAsbestos, Crocidolite results in increased expression of IL6 mRNA; Asbestos, Crocidolite results in increased expression of IL6 proteinPMID:18192500 PMID:23917077 PMID:26678224 PMID:29279043 PMID:29507420
IL6multiple interactionsISOIl6 (Mus musculus)6480464CTDLignans inhibits the reaction [Asbestos, Crocidolite results in increased expression of IL6 protein]; MAP2K1 protein inhibits the reaction [Asbestos, Crocidolite results in increased expression of IL6 mRNA]PMID:18192500 PMID:26678224
Go Back to source page   Continue to Ontology report