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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69218
Species: Mus musculus
RGD Object: Gene
Symbol: Aldh2
Name: aldehyde dehydrogenase 2, mitochondrial
Acc ID: CHEBI:4659
Term: disulfiram
Definition: An organic disulfide that results from the formal oxidative dimerisation of N,N-diethyldithiocarbamic acid. A multi-enzyme inhibitor that is used in alcohol aversion therapy and also exhibits anticancer properties.
Chemical ID: MESH:D004221
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityEXP 6480464CTDDisulfiram metabolite results in decreased activity of ALDH2 protein, Disulfiram results in decreased activity of ALDH2 protein

PMID:10513990, PMID:9585485
decreases activityISORGD:692196480464CTDDisulfiram results in decreased activity of ALDH2 protein

PMID:11142365, PMID:24496638
decreases activityISORGD:692206480464CTDDisulfiram results in decreased activity of ALDH2 protein

PMID:22079344
decreases expressionISORGD:692196480464CTDDisulfiram results in decreased expression of ALDH2 mRNA

PMID:24496638
multiple interactionsISORGD:692196480464CTD[Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyceraldehyde, [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to glycolaldehyde, [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyoxal, [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to hydroxypyruvic acid, [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Pyruvaldehyde

PMID:21334317, PMID:21376711
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.