GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ccn1 | decreases expression | ISO | CCN1 (Homo sapiens) | 6480464 | CTD | Zoledronic Acid results in decreased expression of CCN1 mRNA; Zoledronic Acid results in decreased expression of CCN1 protein | PMID:19530242 | Ccn1 | multiple interactions | ISO | CCN1 (Homo sapiens) | 6480464 | CTD | CCN1 protein affects the reaction [Zoledronic Acid results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; CCN1 protein affects the reaction [Zoledronic Acid results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]; CCN1 protein affects the reaction [Zoledronic Acid results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]; CCN1 protein affects the reaction [Zoledronic Acid results in increased expression of CDKN1A protein]; geranylgeraniol inhibits the reaction [Zoledronic Acid results in decreased expression of CCN1 protein]; Zoledronic Acid promotes the reaction [CCN1 protein affects the expression of CDKN1B protein] | PMID:19530242 | |
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