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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:46557
Term: zoledronic acid
Definition: An imidazole compound having a 2,2-bis(phosphono)-2-hydroxyethane-1-yl substituent at the 1-position.
Chemical ID: MESH:C088658
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2affects expressionISOBCL2 (Homo sapiens)6480464CTDzoledronic acid affects the expression of BCL2 mRNAPMID:19036117
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDzoledronic acid results in decreased expression of BCL2 mRNAPMID:28871336
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDzoledronic acid results in decreased expression of BCL2 mRNAPMID:24714768 PMID:28871336
Bcl2decreases response to substanceISOBCL2 (Homo sapiens)6480464CTDBCL2 protein results in decreased susceptibility to zoledronic acidPMID:11986784
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDZoledronic Acid results in increased expression of BCL2 mRNAPMID:18225567 PMID:35587103
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTD[zoledronic acid co-treated with Doxorubicin] results in decreased expression of BCL2 proteinPMID:19789217
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[Tretinoin co-treated with zoledronic acid] results in decreased expression of BCL2 protein; [zoledronic acid co-treated with docetaxel] results in decreased expression of BCL2 proteinPMID:19103299 PMID:20349282
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