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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:46557
Term: zoledronic acid
Definition: An imidazole compound having a 2,2-bis(phosphono)-2-hydroxyethane-1-yl substituent at the 1-position.
Chemical ID: MESH:C088658
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxdecreases expressionISOBAX (Homo sapiens)6480464CTDzoledronic acid results in decreased expression of BAX mRNAPMID:19036117
Baxincreases expressionISOBax (Mus musculus)6480464CTDzoledronic acid results in increased expression of BAX mRNAPMID:28871336
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDZoledronic Acid results in increased expression of BAX mRNAPMID:28871336 PMID:35587103
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[zoledronic acid co-treated with Doxorubicin] results in increased expression of BAX proteinPMID:19789217
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[Tretinoin co-treated with zoledronic acid] results in increased expression of BAX proteinPMID:20349282
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