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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345118
Species: Homo sapiens
RGD Object: Gene
Symbol: PARP1
Name: poly(ADP-ribose) polymerase 1
Acc ID: CHEBI:46557
Term: zoledronic acid
Definition: An imidazole compound having a 2,2-bis(phosphono)-2-hydroxyethane-1-yl substituent at the 1-position.
Chemical ID: MESH:C088658
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PARP1increases cleavageEXP 6480464CTDzoledronic acid results in increased cleavage of PARP1 proteinPMID:10780527 PMID:20977926
PARP1increases expressionEXP 6480464CTDzoledronic acid results in increased expression of PARP1 mRNAPMID:24714768
PARP1multiple interactionsEXP 6480464CTDarsenic trioxide promotes the reaction [zoledronic acid results in increased cleavage of PARP1 protein]PMID:20977926
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