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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1332548
Species: Mus musculus
RGD Object: Gene
Symbol: Ppargc1a
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
Acc ID: CHEBI:46557
Term: zoledronic acid
Definition: An imidazole compound having a 2,2-bis(phosphono)-2-hydroxyethane-1-yl substituent at the 1-position.
Chemical ID: MESH:C088658
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargc1adecreases expressionEXP 6480464CTDzoledronic acid results in decreased expression of PPARGC1A mRNAPMID:28871336
Ppargc1amultiple interactionsEXP 6480464CTDFenofibrate inhibits the reaction [zoledronic acid results in decreased expression of PPARGC1A mRNA]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in decreased expression of PPARGC1A mRNA]PMID:28871336
Ppargc1adecreases expressionISOPPARGC1A (Homo sapiens)6480464CTDzoledronic acid results in decreased expression of PPARGC1A mRNA; zoledronic acid results in decreased expression of PPARGC1A proteinPMID:24714768 PMID:28871336
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