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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:4653
Term: dipyridamole
Definition: A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.
Chemical ID: MESH:D004176
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDDipyridamole results in increased expression of HMOX1 protein

PMID:19356721
multiple interactionsEXP 6480464CTDHMOX1 mRNA affects the reaction [Dipyridamole results in increased phosphorylation of DUSP1 protein]

PMID:19356721
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.