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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735949
Species: Homo sapiens
RGD Object: Gene
Symbol: RAMP1
Name: receptor activity modifying protein 1
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RAMP1affects response to substanceEXP 6480464CTDRAMP1 protein affects the susceptibility to FluorouracilPMID:15352031
RAMP1decreases expressionEXP 6480464CTDFluorouracil results in decreased expression of RAMP1 proteinPMID:15352031
RAMP1multiple interactionsEXP 6480464CTDRAMP1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]PMID:16896004
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