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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735849
Species: Homo sapiens
RGD Object: Gene
Symbol: EPO
Name: erythropoietin
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EPOincreases response to substanceEXP 6480464CTDEPO protein results in increased susceptibility to FluorouracilPMID:16103069
EPOincreases expressionISOEpo (Rattus norvegicus)6480464CTDFluorouracil results in increased expression of EPO proteinPMID:20020992 PMID:2206997
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