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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735767
Species: Homo sapiens
RGD Object: Gene
Symbol: KRT18
Name: keratin 18
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KRT18affects expressionEXP 6480464CTDFluorouracil affects the expression of KRT18 mRNAPMID:34151400
KRT18multiple interactionsEXP 6480464CTD[Fluorouracil co-treated with irinotecan co-treated with vorinostat] results in increased cleavage of KRT18 proteinPMID:15754201
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