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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735717
Species: Mus musculus
RGD Object: Gene
Symbol: Slc3a2
Name: solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc3a2affects response to substanceISOSLC3A2 (Homo sapiens)6480464CTDSLC3A2 protein affects the susceptibility to FluorouracilPMID:15331170
Slc3a2increases expressionISOSLC3A2 (Homo sapiens)6480464CTDFluorouracil results in increased expression of SLC3A2 mRNAPMID:15331170
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