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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735336
Species: Mus musculus
RGD Object: Gene
Symbol: Akt1
Name: thymoma viral proto-oncogene 1
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1decreases phosphorylationEXP 6480464CTDFluorouracil results in decreased phosphorylation of AKT1 proteinPMID:30542770
Akt1multiple interactionsEXP 6480464CTDFluorouracil inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]PMID:16724238
Akt1affects expressionISOAKT1 (Homo sapiens)6480464CTDFluorouracil affects the expression of AKT1 mRNAPMID:34151400
Akt1affects phosphorylationISOAKT1 (Homo sapiens)6480464CTDFluorouracil affects the phosphorylation of AKT1 proteinPMID:24095863
Akt1increases phosphorylationISOAKT1 (Homo sapiens)6480464CTDFluorouracil results in increased phosphorylation of AKT1 proteinPMID:18794807
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTD[Apigenin co-treated with Fluorouracil] results in decreased expression of AKT1 protein; AG 1879 inhibits the reaction [Fluorouracil results in increased phosphorylation of AKT1 protein]; Fluorouracil results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of AKT1 protein; Nicotine affects the reaction [Fluorouracil affects the phosphorylation of AKT1 protein]PMID:17918158 PMID:18794807 PMID:19885610 PMID:24095863
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