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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733398
Species: Mus musculus
RGD Object: Gene
Symbol: Aldh1a3
Name: aldehyde dehydrogenase family 1, subfamily A3
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh1a3affects response to substanceISOALDH1A3 (Homo sapiens)6480464CTDALDH1A3 protein affects the susceptibility to FluorouracilPMID:15352031
Aldh1a3decreases expressionISOALDH1A3 (Homo sapiens)6480464CTDFluorouracil results in decreased expression of ALDH1A3 proteinPMID:15352031
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