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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732679
Species: Homo sapiens
RGD Object: Gene
Symbol: FEN1
Name: flap structure-specific endonuclease 1
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FEN1affects response to substanceEXP 6480464CTDFEN1 affects the susceptibility to FluorouracilPMID:15067352
FEN1increases expressionEXP 6480464CTDFluorouracil results in increased expression of FEN1 mRNAPMID:15109396
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