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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732480
Species: Homo sapiens
RGD Object: Gene
Symbol: HSPB1
Name: heat shock protein family B (small) member 1
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSPB1decreases response to substanceEXP 6480464CTDHSPB1 protein results in decreased susceptibility to FluorouracilPMID:18949417
HSPB1multiple interactionsEXP 6480464CTDHSPB1 protein affects the susceptibility to [Cisplatin co-treated with Fluorouracil co-treated with Leucovorin]PMID:19088045
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