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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731363
Species: Homo sapiens
RGD Object: Gene
Symbol: CALB2
Name: calbindin 2
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CALB2increases expressionEXP 6480464CTDFluorouracil results in increased expression of CALB2 mRNAPMID:16510598
CALB2increases response to substanceEXP 6480464CTDCALB2 protein results in increased susceptibility to FluorouracilPMID:16510598
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