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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68656
Species:
RGD Object: Gene
Symbol: Dclk1
Name: doublecortin-like kinase 1
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:686556480464CTDTP53 protein affects the reaction [Fluorouracil results in decreased expression of DCLK1 mRNA]

PMID:15016801
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.