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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621419
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kpna2
Name: karyopherin subunit alpha 2
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kpna2decreases expressionISOKPNA2 (Homo sapiens)6480464CTDFluorouracil results in decreased expression of KPNA2 mRNAPMID:17374387
Kpna2multiple interactionsISOKPNA2 (Homo sapiens)6480464CTDTP53 protein affects the reaction [Fluorouracil results in decreased expression of KPNA2 mRNA]PMID:15016801
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