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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9affects expressionISOMMP9 (Homo sapiens)6480464CTDFluorouracil affects the expression of MMP9 mRNAPMID:15205334
Mmp9increases expressionISOMMP9 (Homo sapiens)6480464CTDFluorouracil results in increased expression of MMP9 proteinPMID:26310874
Mmp9multiple interactionsISOMmp9 (Mus musculus)6480464CTDFluorouracil promotes the reaction [Valsartan results in decreased activity of MMP9 protein]PMID:35235860
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