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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621246
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Top1
Name: DNA topoisomerase I
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Top1affects response to substanceISOTOP1 (Homo sapiens)6480464CTDTOP1 protein affects the susceptibility to FluorouracilPMID:18509181
Top1decreases expressionISOTOP1 (Homo sapiens)6480464CTDFluorouracil results in decreased expression of TOP1 mRNAPMID:16709241
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