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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621218
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dpyd
Name: dihydropyrimidine dehydrogenase
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dpydaffects activityISODPYD (Homo sapiens)6480464CTDFluorouracil metabolite affects the activity of DPYD proteinPMID:16761622
Dpydaffects degradationISODPYD (Homo sapiens)6480464CTDDPYD protein affects the degradation of FluorouracilPMID:15858133
Dpydaffects metabolic processingISODPYD (Homo sapiens)6480464CTDDPYD affects the metabolism of Fluorouracil; DPYD protein affects the metabolism of FluorouracilPMID:11148247 PMID:15930747 PMID:18600527
Dpydaffects response to substanceISODPYD (Homo sapiens)6480464CTDDPYD gene polymorphism affects the susceptibility to Fluorouracil; DPYD gene SNP affects the susceptibility to Fluorouracil; DPYD intron polymorphism affects the susceptibility to Fluorouracil; DPYD mRNA affects the susceptibility to Fluorouracil; DPYD promoter modified form affects the susceptibility to Fluorouracil; DPYD protein affects the susceptibility to Fluorouracil; DPYD protein mutant form affects the susceptibility to FluorouracilPMID:10099659 PMID:12562666 PMID:12635664 PMID:15017333 PMID:15655543 PMID:15858133 PMID:15993511 PMID:16361556 PMID:17046731 PMID:17121937 PMID:18197934 PMID:18299612 PMID:18443386 PMID:18619742 PMID:18846242 PMID:18986760 PMID:19020767 PMID:3335642 PMID:8680084 PMID:9816193
Dpyddecreases expressionISODPYD (Homo sapiens)6480464CTDFluorouracil results in decreased expression of DPYD mRNAPMID:15109396 PMID:17330233 PMID:19219653
Dpyddecreases metabolic processingISODPYD (Homo sapiens)6480464CTDDPYD gene polymorphism results in decreased metabolism of Fluorouracil; DPYD protein mutant form results in decreased metabolism of FluorouracilPMID:15591715 PMID:16033824 PMID:18443386
Dpyddecreases response to substanceISODpyd (Mus musculus)6480464CTDDPYD mRNA results in decreased susceptibility to FluorouracilPMID:16525674
Dpyddecreases response to substanceISODPYD (Homo sapiens)6480464CTDDPYD mRNA results in decreased susceptibility to Fluorouracil; DPYD protein results in decreased susceptibility to FluorouracilPMID:14689231 PMID:15246190 PMID:15890242 PMID:15949589 PMID:16282729 PMID:17377791 PMID:18383874 PMID:19105824
Dpydincreases activityISODPYD (Homo sapiens)6480464CTDFluorouracil results in increased activity of DPYD proteinPMID:16557585
Dpydincreases degradationISODPYD (Homo sapiens)6480464CTDDPYD protein results in increased degradation of FluorouracilPMID:17046731
Dpydincreases expressionISODPYD (Homo sapiens)6480464CTDFluorouracil results in increased expression of DPYD mRNA; Fluorouracil results in increased expression of DPYD proteinPMID:15865071 PMID:16568373 PMID:18197934
Dpydincreases metabolic processingISODPYD (Homo sapiens)6480464CTDDPYD protein results in increased metabolism of FluorouracilPMID:15591715 PMID:15993511 PMID:16033824 PMID:16115930 PMID:17064846 PMID:18075467 PMID:18225548
Dpydincreases response to substanceISODPYD (Homo sapiens)6480464CTDDPYD gene mutant form results in increased susceptibility to Fluorouracil; DPYD gene polymorphism results in increased susceptibility to Fluorouracil; DPYD mRNA results in increased susceptibility to FluorouracilPMID:15239142 PMID:17064846 PMID:19104657 PMID:9470816
Dpydmultiple interactionsISODPYD (Homo sapiens)6480464CTD[Cisplatin co-treated with Fluorouracil] results in decreased expression of DPYD mRNA; [docetaxel co-treated with Fluorouracil] results in decreased expression of DPYD mRNA; [Leucovorin co-treated with Fluorouracil] results in decreased activity of DPYD protein; Camptothecin inhibits the reaction [Fluorouracil results in increased expression of DPYD mRNA]; Cisplatin inhibits the reaction [Fluorouracil results in increased expression of DPYD mRNA]; docetaxel inhibits the reaction [Fluorouracil results in increased activity of DPYD protein]; DPYD protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin]; DPYD results in increased susceptibility to [Fluorouracil co-treated with gimeracil]; Fluorouracil inhibits the reaction [docetaxel results in increased expression of DPYD protein]; gimeracil affects the reaction [DPYD protein results in increased susceptibility to Fluorouracil]; gimeracil inhibits the reaction [DPYD protein results in decreased susceptibility to Fluorouracil]; gimeracil inhibits the reaction [DPYD protein results in increased degradation of Fluorouracil]; gimeracil inhibits the reaction [DPYD protein results in increased metabolism of Fluorouracil]PMID:12044515 PMID:15737843 PMID:15949589 PMID:15993511 PMID:16557585 PMID:16568373 PMID:16646564 PMID:19093184 PMID:7503095
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