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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62109
Species: Mus musculus
RGD Object: Gene
Symbol: Col1a1
Name: collagen, type I, alpha 1
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col1a1decreases expressionEXP 6480464CTDFluorouracil results in decreased expression of COL1A1 mRNA; Fluorouracil results in decreased expression of COL1A1 proteinPMID:21296659 PMID:35235860
Col1a1multiple interactionsEXP 6480464CTDFluorouracil promotes the reaction [Valsartan results in decreased expression of COL1A1 mRNA]; Valsartan promotes the reaction [Fluorouracil results in decreased expression of COL1A1 mRNA]PMID:35235860
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