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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620817
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aifm1
Name: apoptosis inducing factor, mitochondria associated 1
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aifm1increases expressionISOAifm1 (Mus musculus)6480464CTDFluorouracil results in increased expression of AIFM1 proteinPMID:32270916
Aifm1multiple interactionsISOAIFM1 (Homo sapiens)6480464CTD[Doxorubicin co-treated with Paclitaxel co-treated with Fluorouracil] results in increased expression of AIFM1 proteinPMID:16168113
Aifm1multiple interactionsISOAifm1 (Mus musculus)6480464CTD[Fluorouracil co-treated with casticin] results in increased expression of AIFM1 proteinPMID:32270916
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