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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620545
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chek1
Name: checkpoint kinase 1
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chek1affects response to substanceISOCHEK1 (Homo sapiens)6480464CTDCHEK1 protein affects the susceptibility to FluorouracilPMID:18698031
Chek1decreases expressionISOChek1 (Mus musculus)6480464CTDFluorouracil results in decreased expression of CHEK1 mRNAPMID:19272435
Chek1increases expressionISOCHEK1 (Homo sapiens)6480464CTDFluorouracil results in increased expression of CHEK1 proteinPMID:15016801
Chek1multiple interactionsISOCHEK1 (Homo sapiens)6480464CTD[CHEK1 protein co-treated with TP53 protein] affects the susceptibility to Fluorouracil; Fluorouracil results in increased phosphorylation of and results in increased activity of CHEK1 protein; TP53 protein affects the reaction [CHEK1 protein affects the susceptibility to Fluorouracil]; TP53 protein affects the reaction [Fluorouracil results in decreased expression of CHEK1 mRNA]; TP53 protein inhibits the reaction [Fluorouracil results in increased expression of CHEK1 protein]PMID:15016801 PMID:18698031 PMID:21613406 PMID:22194930
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